STR null alleles complicate parentage testing in South Africa
نویسندگان
چکیده
منابع مشابه
STR null alleles complicate parentage testing in South Africa.
BACKGROUND Null alleles complicate parentage testing because they do not contribute positively to phenotypes.Objectives. To survey South African populations for null alleles at short tandem repeat (STR) loci used in parentage testing. METHODS Paternity case data were scanned for apparent contradictions compared with Mendelian inheritance that could be due to null alleles. Estimates of null al...
متن کاملRisk analysis of duo parentage testing with limited STR loci.
The aim of this study was to evaluate whether the Goldeneye 20A system (containing 19 short tandem repeats) can avert the shortage of duo parentage tests. Among routine cases typed by the Identifiler system, we identified 42 motherless cases, 2 fatherless cases, and 34 trio cases containing 1 locus mismatch and 4 motherless cases with 2 locus mismatches. One true trio case was rejected by fathe...
متن کاملSTR sequence analysis for characterizing normal, variant, and null alleles.
DNA sequence variation is known to exist in and around the repeat region of short tandem repeat (STR) loci used in human identity testing. While the vast majority of STR alleles measured in forensic DNA laboratories worldwide type as "normal" alleles compared with STR kit allelic ladders, a number of variant alleles have been reported. In addition, a sequence difference at a polymerase chain re...
متن کاملSTR polymorphisms in Sri Lanka: evaluation of forensic utility in identification of individuals and parentage testing.
OBJECTIVES This preliminary study was carried out to determine the allele frequencies and forensic efficiency parameters for the short tandem repeat loci CSF1PO, TPOX, THO1, D16S539, D7S820, D13S317, vWA, FESFPS and F13B in a test sample population of Sri Lankans. DESIGN Test samples were obtained from 305 non-related individuals originating from all 9 provinces of Sri Lanka. DNA was extracte...
متن کاملThe Effect of South African Geopolitical Position in the Development of Cinema in South Africa
This paper will discuss about the role of the geopolitical location of South Africa in the development of movie and the cinema industry in this country. Despite of bringing ci-nema to South Africa by white Europeans, but the development of this phenomenon is mostly due to the geopolitical position of this country. It is interesting to know that ci-nema reached Africa in much the same time as it...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: South African Medical Journal
سال: 2013
ISSN: 2078-5135
DOI: 10.7196/samj.7067